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A species of bacteria that has been linked to both peptic ulcers
and gastric cancer becomes more virulent in the presence of higher
salt concentrations, according to a study presented at the conference
of the American Society for Microbiology.
A bacteria known as Helicobacter pylori
is believed to cause more than 75 percent
of all peptic ulcers, including up to
80 percent of gastric ulcers and up to
90 percent of duodenal ulcers. However,
the presence of H. pylori in the stomach
does not always lead to ulcers or other
noticeable health problems.
Researchers monitored the way that H.
pylori genes expressed themselves under
laboratory conditions, as well as the
bacteria's rate of growth. They found
that higher concentrations of salt caused
the bacteria's growth rate to drop and
caused its shape to change. Under these
conditions, two genes linked to the organism's
virulence were expressed more strongly.
This means that in the presence of salt,
H. pylori is more likely to produce proteins
that cause it to be more dangerous to
humans, and more likely to produce ulcers.
"Apparently H. pylori closely monitors
the diets of those people whom it infects," said
lead researcher Dr. Hanan Gancz of the
Uniformed Services University of the
Health Sciences in Bethesda, Maryland. "We
think that when there are high levels
of salt in the stomach environment, H.
pylori over-produces [the factors that]
enable it to survive, which in the long
term increases the risk of illness."
Gancz also noted that doctors have long
been aware of a link between high salt
intake and increased risk of gastric
cancer. There is also a connection between
H. pylori and gastric cancer risk, although
it is not clear if the relationship is
causal or not. Nevertheless, the International
Agency for Research on Cancer has classified
the bacteria as a carcinogen. Scientists
have speculated that it may increase
the production of free radicals and cell
mutation in its host's body, or that
it might induce local inflammation.
However, this research did not consider
the differences between processed salt
(sodium chloride) and full-spectrum sea
salt (like Celtic sea salt). It may be
that only processed salt causes this
change in the bacteria while sea salt
does a better job of protecting humans. |